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We can’t end animal research without serious consequences

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To the editor: A letter writer implies that animal research has endured due to the scientific neighborhood’s and the pharmaceutical trade’s inertia, laziness and monetary acquire.

As a scientist who witnessed firsthand the research resulting in the event of two extensively used courses of medicine which have alleviated illness in a whole bunch of thousands and thousands — proton-pump inhibitors and gliflozins — I can guarantee the author that if a non-animal different to drug testing that would predict efficacy and all potential opposed results in people grew to become out there, this might be instantly adopted.

Cell tradition, for instance, typically requires fetal calf serum obtained from slaughtered pregnant cows and is thus a type of animal analysis. All medication have to be examined in massive medical trials earlier than approval by the U.S. Meals and Drug Administration, and no drug can enter a medical trial earlier than intensive security testing in animals.

As a lot as everybody, together with the scientific neighborhood, wish to abandon animal analysis, the choice of releasing untested medication to the general public is way worse.

Jonathan Kaunitz, MD, Santa Monica

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Taylor Ward ending season on high note as Angels beat Athletics

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#Taylor #Ward #season #excessive #word #Angels #beat #Athletics

This season has not been the kindest to Taylor Ward. The best way he’s closing it out, although, exhibits he’s a participant who nonetheless might be worthy of reward in seasons to come back.

“I’ve realized so much this 12 months,” Ward stated this month. “It began off actually scorching and sort of cooled off. Simply places a season in perspective of how issues can go and the way it can change drastically.

“In all probability take just a few weeks off [when the season ends] after which deal with getting greater, stronger, sooner. I feel that’s gonna be the largest factor for me is to proceed to exercise nicely [in the offseason] and eat wholesome and actually simply get again to being wholesome.”

Ward has been on a tear by September.

He went two for 4 with a pair of singles and likewise stole a base in the Angels’ 4-3 win over the Oakland Athletics on Tuesday night time.

By means of his final 22 video games earlier than Tuesday, he batted .325 with an on-base-plus-slugging share of .926. He had 4 doubles and 4 residence runs in his 25 hits in that span, contributing 13 RBIs and 13 runs.

His final hitting streak, which lasted 9 video games and ended Saturday, included his ninth three-for-four sport of the season, his thirtieth multi-hit sport of the 12 months, and a two residence run sport. These numbers pale compared with the trajectory he was on in Might earlier than accidents slowed him down.

Ward had been having the very best begin of his profession, throughout a season he opened nursing a groin damage, earlier than a neck stinger Might 20 and a gentle proper hamstring pressure June 3 hampered him and finally sidelined him for nearly half of June.

Earlier than occurring the injured checklist, Ward was batting .333 with a 1.087 OPS — he had an MLB-leading 1.197 OPS at one point — and was a stable All-Star candidate. Hitting coach Jeremy Reed nonetheless believes an All-Star berth is in Ward’s future.

“I assumed he was totally able to having a spot on that roster,” Reed stated this month. “It was one likelihood that isn’t going to be only one likelihood. It’s going to be a number of alternatives for having the prospect to play in that sport.”

Ward’s return from the IL on June 14 wasn’t a full return to kind, and because the season continued, fatigue wore him down extra.

“Accidents I feel took a toll on issues, however simply attempting to stay with the method and proceed to belief your potential even in the event you don’t really feel 100%,” Ward stated. “You gotta sort of persuade your self that every little thing is ok. Attempt not to consider it an excessive amount of. That was one factor I sort of realized a bit of bit, simply to not fear about it and attempt to deal with what it is advisable to do while you’re within the field.”

Within the two months (June 14-Aug 14) after he returned from the IL, Ward was inconsistent on the plate, batting .222 with a .630 OPS.

“You actually spend most of your time attempting to determine what the issue is,” Ward stated. “You need to nonetheless be your self, and it’s simply small tinkering right here and there as a substitute of overhauling one thing.”

Of Ward’s stoop, Reed stated: “There’s additionally some changes that pitchers make after which damage and the fatigue and the size of the season, they’re all elements. You see [Mike Trout], you see [Shohei Ohtani], you see the gamers they’re they usually undergo it. All of them undergo completely different stretches.

“It’s actually, finally about how brief you’ll be able to maintain the dangerous streaks and the way lengthy you’ll be able to stretch the nice streaks. It’s simply good to see him faucet into his full functionality for a great stretch and now we have to reduce the opposite stretches.”

Jo Adell lifts Angels in victory

Angels' Matt Duffy scores ahead of a throw to Oakland Athletics catcher Sean Murphy.

Angels’ Matt Duffy scores forward of a throw to Oakland Athletics catcher Sean Murphy in the course of the eighth inning on Tuesday at Angel Stadium.

(Ashley Landis / Related Press)

Jo Adell’s RBI single within the eighth inning — which scored Matt Duffy, who reached base after getting hit by a pitch — was the tiebreaking hit and propelled the Angels to a victory over the Athletics.

It wasn’t Adell’s solely huge second of the night time. Within the fifth inning, he robbed Dermis Garcia of a possible residence run, leaping up alongside the left-field wall to make the catch.

He cheered in celebration of the play and obtained applause from Patrick Sandoval, who had already given up three runs.

Sandoval went 5 1/3 innings, giving up six hits and three runs.

All three of the A’s runs scored within the second inning. However the Angels tied it up with three of their very own within the backside of the inning.

Mike Ford and Duffy received back-to-back hits off A’s starter James Kaprielian. Matt Thaiss drove within the first runner, Ford, on a single of his personal. Duffy was pushed in on a sacrifice fly by Livan Soto, and Thaiss was introduced in on Luis Rengifo’s single.

Soto, who has been having an thrilling entrance to the large leagues this month, additionally hit his first profession triple within the sixth.

Anthony Rendon replace

Anthony Rendon took reside pitches from three Angels minor leaguers, Caden Dana, Chase Chaney and Mason Albright, earlier than Tuesday’s sport.

“He swung the bat good, he felt good,” Angels interim supervisor Phil Nevin stated. “We’ll see how he feels tomorrow getting into. We’ll have some pitchers right here which can be accessible to throw to him once more tomorrow if he feels up for it.”

The plan is for him to proceed taking reside pitches as a part of his development.

There are eight video games remaining this season.

Archie Bradley’s return

Aid pitcher Archie Bradley was activated from the injured checklist earlier than Tuesday’s sport, practically three months to the day from when he fractured his elbow falling over the dugout railing attempting to get to a brawl between his group and the Seattle Mariners.

“Even in these first couple of days after breaking it, I didn’t suppose I’d be standing right here pitching this season,” Bradley stated. “I’m simply blissful that I used to be capable of get well and be right here and be with the fellows and shut the season within the huge leagues.

“After I lay my head down at night time, I nonetheless take into consideration the season and the influence I might’ve had,” he stated. “Not saying that issues would’ve been completely different, however I feel I convey one thing to the desk. So it begins with displaying Perry [Minasian], present the Angels that I’m nonetheless a great high quality main league pitcher.”

Bradley, who signed a one-year take care of the Angels, turns into a free agent after this season.

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Lakers open camp with competition for starting lineup

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#Lakers #open #camp #competitors #beginning #lineup


Of every thing the Lakers have to do — implement new schemes on each side of the ball, purchase into a brand new coach’s philosophy, stay wholesome and mesh as teammates — determining the beginning lineup truly is low on Darvin Ham’s precedence record.

“Individuals get so caught up in who’s beginning and this, that and the third. I believe it’s actually the minutes,” Ham mentioned Tuesday after his first apply as Lakers coach. “And for me it’s about who finishes the sport as nicely. That’s virtually simply as essential or no more essential than who begins.”

Attempt telling that to the followers, and albeit, to the gamers.

“I do know I wish to begin,” wing Juan Toscano-Anderson mentioned. “I’m not going to be mad if I don’t begin. However yeah, I might love to begin. If the chance is there, I’m gonna attempt to seize it.”

And if Toscano-Anderson, a 29-year-old who grinded his means from the professional leagues in Mexico and the minors within the U.S. to earn a spot within the NBA, desires a spot within the first 5, it’s a secure guess Russell Westbrook does too.

Westbrook’s future with the Lakers has been open to hypothesis for the reason that summer time, his title introduced up not solely in commerce discussions, but additionally in contemplating the potential of the previous most useful participant coming off the bench.

Requested if he envisioned Westbrook beginning with LeBron James and Anthony Davis offered that Westbrook commits to protection the best way Ham’s requested, the coach mentioned he “completely” seen Westbrook as one in all his first 5.

“I do know there’s this narrative that’s being thrown on the market that I by no means mentioned, you understand what I’m saying?” Ham mentioned. “Like, it’s loopy. I imply, what goes on on this constructing, what goes on with the conversations with Rob [Pelinka], Russ and myself, his agent Jeff [Schwartz]. …It’s a must to maintain your tongue loads, select to not converse on issues. However then folks draw totally different situations out of your silence, which is loopy. However he was there entrance and heart in the present day and did nicely, introduced a ton of nice power to the gymnasium.”

A day earlier when requested about the start line guard choices, Ham implied that there might be a full-on camp competitors. Requested if Westbrook was the definitive starter, Ham didn’t say sure.

“Now we have a wide range of choices to fill in our backcourt,” he mentioned Monday. “However once more, as I discussed, defensively, we’ve received to have a defensive mindset. These are the blokes who’re going to get the minutes, guys who’re going on the market to get stops. And he’s informed me personally that he’s going to decide to that aspect of the ball. And that’s what camp is for. We’ll see. Now we have greater than sufficient choices that we’re snug with.”

The Lakers added two veteran guards in Patrick Beverley and Dennis Schroder, although they’ve maintained the strikes are extra about depth and complementing what Westbrook can do. Westbrook has mentioned his job is to be skilled and do regardless of the workforce wants, however he hasn’t come off the bench since 2008, his rookie season.

To this point, Westbrook has appeared snug with Ham — smiling when speaking in regards to the plans for rushing up the workforce’s tempo.

“His power. His willpower. His will to only make certain we’re locked in on our new schemes and phrases,” Westbrook mentioned of Ham’s first apply. “That’s one thing that I stay up for. I’m simply blissful to be part of that.”

If Westbrook is certainly going to begin, the Lakers nonetheless have questions on who will be a part of him, James and Davis — or a minimum of Ham’s not saying.

“I had Kareem, James Worthy, Byron Scott,” Ham joked about his first-day starters earlier than reiterating that he desires his choices open. “…We received numerous nice gamers and we’re going to guage correctly. And we’ll see.”

The message

Earlier than the Lakers took the court docket for his or her first apply, Ham gathered the workforce within the movie room — an odd spot with no sport or apply video but obtainable. As a substitute, he spoke about his expectations with a sequence of slides illustrating his factors and core ideas.

“Laid down some home guidelines within the movie room,” guard Kendrick Nunn mentioned.

Defensively, Ham mentioned, the philosophy is “include, contest and management.” Offensively, it’s “quick, bodily and enjoyable.”

“All of us received collectively within the theater and form of went over some slides,” Ham mentioned. “A tone we wish to set by way of what our id shall be going into the season by way of how we strategy the sport, how we play the sport, the defensive mindset, being nice teammates, being aggressive. And we got here out on the court docket and we proceeded to try this. Planted the seeds for what this new Lakers, the ’22-23 Lakers, will seem like.”

And so forth.

Nunn, who missed all of final season due to a knee harm, mentioned he feels even stronger than he did earlier than the harm, with Tuesday’s apply being a little bit of a milestone in his restoration. “However I’ve additionally been caught within the grind proper now. It’s been weeks and months of simply stacking these days on prime of each other,” Nunn mentioned. “But it surely undoubtedly felt good although.” … Lonnie Walker IV (ankle) and Troy Brown Jr. (again) missed apply, although Walker was doing taking pictures drills afterward. … Ham mentioned latest camp signees Matt Ryan and Dwayne Bacon may compete for the ultimate roster spot. “These are guys that may actually match our workforce simply in the event that they carry out as they need to,” he mentioned. … The Lakers formally introduced Ham’s teaching employees with Chris Jent (previously with Atlanta), Jordan Ott (Brooklyn), J.D. Dubois (Detroit), Schuyler Rimmer (Milwaukee) and Zach Peterson (Oklahoma Metropolis) becoming a member of the group.

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Muscled-up Kawhi Leonard holds court in Clippers’ camp opener

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#Muscledup #Kawhi #Leonard #holds #courtroom #Clippers #camp #opener


One after the other, the Clippers arrived Tuesday morning in an auspicious begin to their season.

Norman Powell was first contained in the health club on the UNLV campus, the veteran with the said objectives of changing into an All-Star and beginning taking pictures guard quickly launching jumpers over coaches’ protection 90 minutes earlier than apply formally started. By the entrance door got here the younger Clippers on the training-camp contracts of their team-issued, Nike-sponsored apply gear. From a facet door monitored by a safety officer, in walked Kawhi Leonard in his New Steadiness T-shirt and shorts.

Level guard John Wall laced up his sneakers whereas chatting with group advisor Jerry West. The guard with whom Wall will compete for the beginning job, Reggie Jackson, fist-bumped anybody inside attain. Middle Ivica Zubac, who turned an ankle taking part in for Croatia throughout this month’s EuroBasket match, walked in with none obvious ache.

The primary day of apply had begun — the primary day with a wholly wholesome Clippers roster for the reason that spring of 2021.

“It feels good to see everybody wholesome,” coach Tyronn Lue stated earlier than apply, “and again on the ground.”

The Clippers know they’ve sufficient top-end expertise to compete for the franchise’s first championship. They imagine they possess sufficient taking pictures and depth to assist such ambition too. What they lack in sheer rim-protecting dimension, they hope to compensate for with their sheer variety of choices to plug in at middle.

What nobody is aware of is how wholesome they are going to be come the postseason’s begin in April, which is why a phalanx of medical staffers adopted the Clippers into the health club Tuesday and why the primary day felt to the Clippers like a very good one after Leonard regarded sturdy throughout full-contact, five-on-five conditions.

“I imply, it’s simply good to see him on the courtroom taking pictures and fairly quickly taking part in basketball video games with us,” wing Nicolas Batum stated earlier than apply. “To have a man like that again, among the best gamers on the earth, among the best gamers within the league, it’s gonna be good for us.”

Mentioned Jackson of title expectations: “A part of the joy, too, is to know that on paper that everyone — lots of people — most likely selecting us, and it appears to be like good on paper.”

The primary apply turned principle into actuality. Within the portion open to reporters earlier than apply, Leonard labored on off-the-dribble taking pictures. It got here in the future after Leonard stated his plan was to take part within the first practices, with the remainder of his involvement all through the preseason decided by the response of his surgically repaired proper knee and the remainder of his 31-year-old physique. The Clippers will apply three days right here earlier than flying to Seattle on Thursday, the place they are going to play two preseason video games and maintain practices whereas closing out coaching camp.

“It’s been 14 months of me simply attempting to higher myself and simply give attention to my general physique,” Leonard stated Monday. “I’m excited. I’m uninterested in going via these rehab exercises and listening to docs and trainers for essentially the most half. Regardless that I’m nonetheless going to need to transferring ahead, however it’ll be extra basketball concerned. That may assist me.”

Teammates, identical to followers on social media, took discover of the muscle Leonard added throughout his restoration, significantly in his legs.

“His restoration’s going effectively,” wing Terance Mann stated, “and he’s Kawhi, so he’ll be all proper.”

Tuesday’s opening of camp didn’t require introductions. Of the ten Clippers who performed no less than 1,000 minutes final season, eight are again and that determine doesn’t embody acquainted faces whose minutes have been restricted after arriving through commerce at midseason, Robert Covington and Powell, nor second-year returners Brandon Boston Jr. and Jason Preston. That mixture of continuity and well being ought to make this “completely different than most coaching camps,” Lue stated, in that practices can advance to scrimmaging sooner than traditional.

These early lineups may replicate some with no conventional middle. Moses Brown, a 7-foot-2 middle on a coaching camp contract, will “get a chance,” Lue stated, however in a season when the Clippers’ rotation is more likely to really feel a squeeze with extra deserving gamers than accessible minutes, Mann and Batum stated they might play any position requested of them, together with middle.

“Taking part in small — I believe it’s extra necessary to play small with Kawhi and [Paul George] on the ground,” Lue added. “I believe having [Zubac] come out early and pop and return with the second unit so we can assist the rebounding, I believe will probably be higher for us as a result of Kawhi and PG are nice rebounders.”

Lue has stated he desires a targeted however free environment throughout camp, with gamers conscious of the numerous alternative forward of them. He had by no means did not make the playoffs as a head coach till final season, and although he spent his offseason attempting to be extra affected person, he additionally has little persistence for the sort of wavering focus that would waste helpful apply repetitions and price the Clippers an opportunity to succeed in their championship ambitions.

He had their consideration at 10:02 a.m., when a buzzing horn rang all through the Clippers’ short-term Vegas house and 20 gamers encircled Lue. The coach regarded out and noticed a rarity — his group absolutely wholesome.

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